The Cori's have been consistently interested in the mechanism of action of hormones and they have carried out several studies on the pituitary. They observed that the marked decrease in glycogen and lowering of blood sugar in hypophysectomized rats occurred with a concomitant increase in the rate of glucose oxidation. Subsequently, by a study of the action of hormones on hexokinase, they observed that some pituitary extracts inhibit this enzyme in vivo and in vitro and that insulin counteracts this inhibition.
It doesn't seem to need rephrasing. What would be the object of rephrasing? Everything flows quite logically from the initial statement about the Cori's consistent interest in hormones. If you're feeling anxious about it, don't be. It's OK.
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